G6PD Pre-design Chimera RNAi
产品名称： G6PD Pre-design Chimera RNAi
英文名称： G6PD Pre-design Chimera RNAi
产品编号： H00002539-R02
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Homo sapiens glucose-6-phosphate dehydrogenase (G6PD), transcript variant 2, mRNA
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_001042351
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 2539
- Gene Name:
- G6PD
- Gene Alias:
- G6PD1
- Gene Description:
- glucose-6-phosphate dehydrogenase
- Omim ID:
- 305900
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000026034,glucose-6-phosphate 1-dehydrogenase,glucose-6-phosphate dehydrogenase, G6PD
- Related Disease
- alpha-Thalassemia
- Anemia
- Anemia, Hemolytic, Congenital Nonspherocytic
- Anemia, Sickle Cell
- Anemia, sickle cell
- beta-Thalassemia
- Birth Weight
- Cardiovascular Diseases
- Coronary Disease
- Diabetes Mellitus, Type 2
- Diabetic Ketoacidosis
- Disease Susceptibility
- Edema
- Elliptocytosis, Hereditary
- Encephalitis
- Favism
- Genetic Predisposition to Disease
- Gilbert Disease
- Glucosephosphate Dehydrogenase Deficiency