GSTM1/GSTM2 polyclonal antibody
产品名称： GSTM1/GSTM2 polyclonal antibody
英文名称： GSTM1/GSTM2 polyclonal antibody
产品编号： PAB6728
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of GSTM1/GSTM2.
- Immunogen:
- A synthetic peptide corresponding to human GSTM1/GSTM2.
- Sequence:
- CVFSKMAVWGNK
- Host:
- Goat
- Theoretical MW (kDa):
- 25.7, 21.3, 25.7
- Reactivity:
- Human
- Specificity:
- This antibody is expected to recognize both reported variants of human GSTM1 protein (NP_000552, NP_666533) and wil also recognize human GSTM2 protein (NP_000848).
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene.
Endo K, Uno S, Seki T, Ariga T, Kusumi Y, Mitsumata M, Yamada S, Makishima M.Toxicol Appl Pharmacol. 2008 Jul 15;230(2):135-43. Epub 2008 Feb 21.
- Entrez GeneID:
- 2944
- Protein Accession#:
- NP_000552 (Gene ID : 2944);NP_666533 (Gene ID : 2946);NP_000839 (Gene ID : 2946)
- Gene Name:
- GSTM1
- Gene Alias:
- GST1,GSTM1-1,GSTM1a-1a,GSTM1b-1b,GTH4,GTM1,H-B,MGC26563,MU,MU-1
- Gene Description:
- glutathione S-transferase mu 1
- Omim ID:
- 138350
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq
- Other Designations:
- GST class-mu 1,HB subunit 4,OTTHUMP00000013346,OTTHUMP00000013347,S-(hydroxyalkyl)glutathione lyase,glutathione S-alkyltransferase,glutathione S-aralkyltransferase,glutathione S-aryltransferase,glutathione S-transferase M1
- Entrez GeneID:
- 2946
- Protein Accession#:
- NP_000552 (Gene ID : 2944);NP_666533 (Gene ID : 2946);NP_000839 (Gene ID : 2946)
- Gene Name:
- GSTM2
- Gene Alias:
- GST4,GSTM,GSTM2-2,GTHMUS,MGC117303
- Gene Description:
- glutathione S-transferase mu 2 (muscle)
- Omim ID:
- 138380
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq
- Other Designations:
- GST class-mu 2,GST, muscle,OTTHUMP00000013351,S-(hydroxyalkyl)glutathione lyase M2,glutathione S-alkyltransferase M2,glutathione S-aralkyltransferase M2,glutathione S-aryltransferase M2,glutathione S-transferase 4,glutathione S-transferase M1,glutathione