FITC标记的尿调节蛋白抗体
产品名称： FITC标记的尿调节蛋白抗体
英文名称： Anti-Uromucoid/FITC
产品编号： HZ-2189R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-Uromucoid/FITC Conjugated antibody
FITC标记的尿调节蛋白抗体
| 英文名称 | Anti-Uromucoid/FITC |
| 中文名称 | FITC标记的尿调节蛋白抗体 |
| 别 名 | UMOD; ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; medullary cystic kidney disease 2 (autosomal dominant); Tamm Horsfall glycoprotein; Tamm Horsfall urinary glycoprotein; Tamm-Horsfall urinary glycoprotein; THGP; THP; Umod; UROM_MOUSE; uromodulin (uromucoid, Tamm-Horsfall glycoprotein); Uromodulin; Uromodulin, secreted form. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 61/65kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse MCKD2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]. Function: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial (By similarity). Uromodulin, secreted form: Secreted into urine after proteolytically cleaveage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals. Subcellular Location: Apical cell membrane; Lipid-anchor, GPI-anchor (By similarity). Basolateral cell membrane; Lipid-anchor, GPI-anchor (By similarity). Cell projection, cilium membrane (By similarity). Note=Only a small fraction is sorts to the basolateral pole of tubular epithelial cells compared to apical localization (By similarity). Uromodulin, secreted form: Secreted (By similarity). Post-translational modifications: N-glycosylated. Similarity: Contains 3 EGF-like domains. Contains 1 ZP domain. Database links: Entrez Gene: 7369 Human Omim: 191845 Human SwissProt: P07911 Human Unigene: 654425 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
在生理条件下，该基因编码的蛋白质是哺乳动物尿液中最丰富的蛋白质。它在尿中的排泄遵循其糖基磷脂酰肌苷锚定对应物的外域的蛋白水解裂解，糖基磷脂酰肌苷锚定对应物位于亨利袢的管腔细胞表面。这种蛋白可以作为肾流体钙结晶的组成抑制剂。尿中排泄这种蛋白质可以预防尿路感染引起的尿路感染。该基因的缺陷与肾脏疾病、髓质囊性肾病-2(MCKD2)、肾小球囊性肾病伴高尿酸血症和异构尿(GCKDHI)以及家族性青少年高尿酸肾病(FJHN)有关。该基因的选择性剪接导致多个转录变体。[ RefSeq，JUL 2013 ]提供。