FITC标记的多囊肾蛋白1样3抗体
产品名称： FITC标记的多囊肾蛋白1样3抗体
英文名称： Anti-PKD1L3/FITC
产品编号： HZ-11622R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PKD1L3/FITC Conjugated antibody
FITC标记的多囊肾蛋白1样3抗体
| 产品编号 | bs-11622R-FITC |
| 英文名称 | Anti-PKD1L3/FITC |
| 中文名称 | FITC标记的多囊肾蛋白1样3抗体 |
| 别 名 | PC1 like 3 protein; Polycystic kidney disease 1 like 3; Polycystic kidney disease protein 1 like 3; Polycystin 1 like 3; Polycystin 1L3;PK1L3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 通道蛋白 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 193kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PKD1L3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Polycystin-1L3 is a 1,732 amino acid multi-pass membrane protein that contains one PLAT domain, one GPS domain and one C-type lectin domain. Expressed at high levels in placenta and present at lower levels in lung and heart, Polycystin-1L3 is thought to function as an ion-channel regulator that may interact with Polycystin-L and play a role in heteromeric taste channels. The gene encoding Polycystin-1L3 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition. Function: PKD1L3 belongs to the polycystin family. It may function as an ion-channel regulator and may function with PKD2L1 as heteromeric taste channels. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in placenta, weakly in heart and lung. Similarity: Belongs to the polycystin family. Contains 1 C-type lectin domain. Contains 1 GPS domain. Contains 1 PLAT domain. Database links: Entrez Gene: 342372 Human Omim: 607895 Human SwissProt: Q7Z443 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
多囊蛋白1L3是一个1732个氨基酸的多通道膜蛋白，含有一个平台结构域、一个GPS域和一个C型凝集素结构域。在胎盘中高表达，在肺和心脏中的水平较低，多囊蛋白1L3被认为是与多囊蛋白-1相互作用的离子通道调节器，在异味通道中起作用。编码多囊蛋白1L3的基因映射到人类16号染色体上，编码900个以上的基因，并包含人类基因组的近3%。GaN基因位于16号染色体上，具有突变，可能导致巨大轴突神经病变，神经系统疾病的特征是随着生长的增加而增加。罕见的Rubinstein Taybi综合征也与16号染色体相关，如Crohn氏病，这是胃肠道炎症状态。