ADH5 Pre-design Chimera RNAi
产品名称： ADH5 Pre-design Chimera RNAi
英文名称： ADH5 Pre-design Chimera RNAi
产品编号： H00000128-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
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- Specification
- Product Description:
- Homo sapiens alcohol dehydrogenase 5 (class III), chi polypeptide (ADH5), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_000671
- Target Region:
- Coding sequence
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 128
- Gene Name:
- ADH5
- Gene Alias:
- ADH-3,ADHX,FDH,GSNOR
- Gene Description:
- alcohol dehydrogenase 5 (class III), chi polypeptide
- Omim ID:
- 103710
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq
- Other Designations:
- alcohol dehydrogenase (class III), chi polypeptide,class III alcohol dehydrogenase 5,formaldehyde dehydrogenase,glutathione-dependent formaldehyde dehydrogenase
- Related Disease
- Alcoholism
- Asthma
- Asthma
- Cleft Lip
- Cleft Palate
- Disease Models, Animal
- Diseases in Twins
- Flushing
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Hearing Loss
- Hypersensitivity, Immediate
- Lymphoma, Non-Hodgkin
- Narcolepsy
- Neoplasm Recurrence, Local
- Neoplasms, Second Primary
- Substance-Related Disorders