小鼠抗MB21D1蛋白单克隆抗体
产品名称： 小鼠抗MB21D1蛋白单克隆抗体
英文名称： MB21D1/ C6orf150
产品编号： hzm-51379M
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： WB=1:1000-5000 ELISA=1:500-5000
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Mouse Anti-MB21D1/ C6orf150 antibody
| 产品编号 | hzm-51379M |
| 英文名称 | MB21D1/ C6orf150 |
| 中文名称 | 小鼠抗MB21D1蛋白单克隆抗体 |
| 别 名 | Mab-21 Domain Containing 1; Mab-21 Domain-Containing Protein 1; Cyclic GMP-AMP Synthase; 23-CGAMP Synthase; CGAMP Synthase; C6orf150; H-CGAS; CGAS; Chromosome 6 Open Reading Frame 150; Protein MB21D1; EC 2.7.7.86; CGAS_HUMAN; Hypothetical protein LOC115004; Mab 21 domain containing 1; MGC131892; MGC142166; MGC142168; OTTHUMP00000016743; OTTHUMP00000039330; protein MB21D1; Uncharacterized protein C6orf150; |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Mouse |
| 克隆类型 | Monoclonal |
| 克 隆 号 | 7E3 |
| 交叉反应 | Human, |
| 产品应用 | WB=1:1000-5000 ELISA=1:500-5000 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 59kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MB21D1/ C6orf150: |
| 亚 型 | IgG1 |
| 纯化方法 | affinity purified by Protein G |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: MB21D1 (Mab-21 Domain Containing 1) is a Protein Coding gene. Diseases associated with MB21D1 include Aicardi-Goutieres Syndrome and Renpenning Syndrome. Among its related pathways are Innate Immune System and Cytosolic sensors of pathogen-associated DNA. GO annotations related to this gene include GTP binding and cyclic-GMP-AMP synthase activity. Function: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2,5 phosphodiester linkage at the GpA step and the formation of a 3,5 phosphodiester linkage at the ApG step, producing c[G(2,5)pA(3,5)p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115). (Microbial infection) Upon M.tuberculosis infection THP-1 cells knocked-out for this gene have impaired type-I interferon production (IF-1 beta), nor do they produce type-I IFN upon transfection with dsDNA (PubMed:26048138). Subcellular Location: Cytoplasm, cytosol. Tissue Specificity: Expressed in the monocytic cell line THP1. Similarity: Belongs to the mab-21 family. SWISS: Q8N884 Gene ID: 115004 Database links: Entrez Gene: 115004 Human Omim: 613973 Human SwissProt: Q8N884 Human Unigene: 658405 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |