HLA-G monoclonal antibody, clone 87G (PE)
产品名称: HLA-G monoclonal antibody, clone 87G (PE)
英文名称: HLA-G monoclonal antibody, clone 87G (PE)
产品编号: MAB5094
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against HLA-G.
- Immunogen:
- HLA-B27 transgenic mice were imunized with H-2 identical murine cells transfected with and expressing genes encoding HLA-G and human beta2-microglobulin.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- This antibody recognizes both membrane-bound and soluble forms of HLA-G (HLA-G1 and HLA-G5). This antibody blocks interaction of HLA-G with inhibitory receptors.
- Form:
- Liquid
- Conjugation:
- PE
- Concentration:
- 0.1 mg/mL
- Isotype:
- IgG2a
- Storage Buffer:
- In PBS (0.2% BSA, 15 mM sodium azide)
- Storage Instruction:
- Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (1:10)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells.
LeMaoult J, Caumartin J, Daouya M, Favier B, Le Rond S, Gonzalez A, Carosella ED.Blood. 2007 Mar 1;109(5):2040-8. Epub 2006 Oct 31.
- 2.
- The surface expression of HLA-F on decidual trophoblasts increases from mid to term gestation.
Shobu T, Sageshima N, Tokui H, Omura M, Saito K, Nagatsuka Y, Nakanishi M, Hayashi Y, Hatake K, Ishitani A.J Reprod Immunol. 2006 Dec;72(1-2):18-32. Epub 2006 Jun 27.
- 3.
- HLA-G proteins in cancer: do they provide tumor cells with an escape mechanism?
Rouas-Freiss N, Moreau P, Ferrone S, Carosella ED.Cancer Res. 2005 Nov 15;65(22):10139-44.
- Application Image
- Flow Cytometry
- Entrez GeneID:
- 3135
- Gene Name:
- HLA-G
- Gene Alias:
- MHC-G
- Gene Description:
- major histocompatibility complex, class I, G
- Gene Ontology:
- Hyperlink
- Gene Summary:
- HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq
- Other Designations:
- HLA class I molecule,HLA-G histocompatibility antigen, class I, G,MHC class I antigen,OTTHUMP00000039485,b2 microglobulin
- Related Disease
- Abortion, Habitual
- Abortion, Spontaneous
- Anemia, Sickle Cell
- Arthritis, Juvenile Rheumatoid
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Autoimmune Diseases
- Behcet Syndrome
- Birth Weight
- Bronchial Hyperreactivity
- Carcinoma, Transitional Cell
- Cardiomyopathy, Dilated
- Cardiovascular Diseases
- Cervical Intraepithelial Neoplasia
- Cholestasis, Intrahepatic
- Chorioamnionitis
- Colitis, Ulcerative
- Coronary Aneurysm