FITC标记的减数分裂内切酶EME1抗体
产品名称： FITC标记的减数分裂内切酶EME1抗体
英文名称： Anti-EME1/FITC
产品编号： HZ-7861R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-EME1/FITC Conjugated antibody
FITC标记的减数分裂内切酶EME1抗体
| 英文名称 | Anti-EME1/FITC |
| 中文名称 | FITC标记的减数分裂内切酶EME1抗体 |
| 别 名 | Crossover junction endonuclease EME1; Eme1 essential meiotic endonuclease 1 homolog 1 (S. pombe); EME1, S. pombe, homolog of, 1; essential meiotic endonuclease 1 homolog 1 (S pombe); Essential Meiotic Endonuclease 1 Homolog 1; essential meiotic endonuclease 1 homolog 2; Essential meiotic endonuclease 1, S. pombe, homolog of, 1; hMMS4; homolog of yeast EME1 endonuclease; MMS4; MMS4 homolog; MMS4L; EME1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 干细胞 细胞周期蛋白 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 63kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EME1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: EME1 complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein (MUS81) to form an endonuclease complex which cleaves branched DNA structures, especially those arising during stalled DNA replication. The protein may be involved in repairing DNA damage and in maintaining genomic stability. It interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. Alternative splicing results in multiple transcript variants. Function: Interacts with MUS81 to form a DNA structure-specificendonuclease with substrate preference for branched DNA structureswith a 5'-end at the branch nick. Typical substrates include3'-flap structures, replication forks and nicked Hollidayjunctions. May be required in mitosis for the processing of stalledor collapsed replication forks. Subunit: May self-associate. Interacts with MUS81. Interacts withERCC4 and FANCM. Subcellular Location: Nucleus, nucleolus. Note=Recruited toregions of DNA damage in S-phase cells. Similarity: Belongs to the EME1/MMS4 family. Database links: UniProtKB/Swiss-Prot: Q96AY2.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
EME1与甲基磺酸甲酯敏感的紫外敏感的81蛋白（MUS1）复合，形成内切核酸酶复合体，其切割分支DNA结构，特别是在停滞DNA复制过程中产生的分支结构。该蛋白可能参与修复DNA损伤和维持基因组稳定性。它与特定的DNA结构相互作用，包括缺口霍利迪连接，3’-瓣结构和异常复制叉结构。选择性剪接导致多个转录变体。