CCNE1 monoclonal antibody, clone SP146
产品名称： CCNE1 monoclonal antibody, clone SP146
英文名称： CCNE1 monoclonal antibody, clone SP146
产品编号： MAB11046
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit monoclonal antibody raised against synthetic peptide of CCNE1.
- Immunogen:
- A synthetic peptide corresponding to near C-terminus of human CCNE1.
- Host:
- Rabbit
- Theoretical MW (kDa):
- 50
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A/G purification
- Isotype:
- IgG
- Storage Buffer:
- In PBS, pH 7.6 (1% BSA, less than 0.1% sodium azide)
- Storage Instruction:
- Store at 4°C. Do not freeze.
- Recommend Usage:
- Immunohistochemistry (1:100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Entrez GeneID:
- 898
- Gene Name:
- CCNE1
- Gene Alias:
- CCNE
- Gene Description:
- cyclin E1
- Omim ID:
- 123837
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq
- Other Designations:
- cyclin Es,cyclin Et
- Interactome
