FITC标记的前动力蛋白2抗体
产品名称： FITC标记的前动力蛋白2抗体
英文名称： Anti-PROK2/FITC
产品编号： HZ-5784R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-PROK2/FITC Conjugated antibody
FITC标记的前动力蛋白2抗体
| 英文名称 | Anti-PROK2/FITC |
| 中文名称 | FITC标记的前动力蛋白2抗体 |
| 别 名 | BV8; Bv8 homolog; MIT1; PK2; PROK2; PROK2_HUMAN; Prokineticin-2; Protein Bv8 homolog. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 免疫学 神经生物学 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 11kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PROK2/Prokineticin 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Prokineticin 2 is known to regulate many different biological functions, including neurogenesis, smooth muscle contractility, angiogenesis and circadian rhythm. In serving the latter role, prokineticin 2 functions as an output molecule from the suprachiasmatic nucleus (SCN) of the hypothalamus, that transmits behavioral rhythms, but may also function locally within the SCN to synchronize output. Prokineticin 2 expression is induced by CLOCK and BMAL1 heterodimers and light, and is inhibited by period genes (PER1, PER2 and PER3) and cryptochrome genes (CRY1 and CRY2). Expression is reported in the SCN and among a few other discrete brain areas, including the islands of Calleja, media l preoptic area of the hypothalamus and the shell of the nucleus accumbens as well as in the testis, prostate and, at lower levels, in the small intestine. Function: May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle. Subcellular Location: Secreted. Tissue Specificity: Expressed in the testis and, at low levels, in the small intestine. DISEASE: Hypogonadotropic hypogonadism 4 with or without anosmia (HH4) [MIM:610628]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the AVIT (prokineticin) family. Database links: Entrez Gene: 60675 Human Entrez Gene: 50501 Mouse Entrez Gene: 192206 Rat Omim: 607002 Human SwissProt: Q9HC23 Human SwissProt: Q9QXU7 Mouse SwissProt: Q8R413 Rat Unigene: 528665 Human Unigene: 87365 Mouse Unigene: 211872 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
促动蛋白2已知调节许多不同的生物学功能，包括神经发生、平滑肌收缩、血管生成和昼夜节律。在为后者发挥作用时，促动力蛋白2作为下丘脑视交叉上核（SCN）的输出分子，其传递行为节律，但也可在SCN内局部发挥作用以同步输出。由时钟和BMAL1异源二聚体和光诱导前体蛋白2的表达，并被周期基因（Pr1、Pr2和Pr3）和隐色基因（Cyr1和Cyr2）抑制。表达在SCN和其他一些离散的脑区，包括Caljja岛，下丘脑的媒体L视前区和伏隔核的外壳，以及在睾丸，前列腺，在较低的水平，在小肠中。