用途及描述：科研试剂，广泛应用于分子生物学，药理学等科研方面。雷帕霉素（西罗莫司）是新型大环内酯的抗排斥药物，是目前世界上最新的强效免疫抑制剂。本品抑制由抗原和细胞因子（白介素IL-2、IL-4和IL-15）激发的T淋巴细胞的活化和增殖，它亦抑制抗体的产生。在细胞中，西罗莫司与免疫嗜素，即FK结合蛋白-12（FKBP-12）结合，生成FKBP-12免疫抑制复合物。此复合物与哺乳动物的西罗莫司BA分子（mTOR，一种关键的调节激酶）结合并抑制其活性，从而抑制细胞周期中G1期向S期的发展。
储存条件：-20℃，避光防潮密闭干燥。

Product Description

Macrocyclic-triene antibiotic possessing potent immunosuppressant activity. It forms a complex with FKBP12 that binds to an effector, thus inhibiting IL-2 and other growth promoting lymphokines. The effectors were recently identified as FRAP (FKBP12 rapamycin-associated protein) and RAFT1 (rapamycin and KFBP12target). Rapamycin induces inhibition of p70s6k, p33cdk2 and p34cdc2. Enhances apoptosis.SOURCE/HOST: Isolated from Streptomyces hygroscopicus.

PURITY: 98% (HPLC)

APPEARANCE: White to off-white powder.

SOLUBILITY: Soluble in chloroform, DMSO or methanol.

SHIPPING: AMBIENT

LONG TERM STORAGE: -20°C

HAZARD: TOXIC.

北京索莱宝科技有限公司目前备有现货1500种，当天即可发货，可以满足大部分高等院校以及高级研究所的实验要求，同时省去您焦急等待的时间。欢迎前来咨询。
公司展台 solarbio.bioon.com.cn  

参考文献：

《IGFBPrP1 accelerates autophagy and activation of hepatic stellate cells via mutual regulation between H19 and PI3K/AKT/mTOR pathway》 作者:Ting-Juan Huang，Jun-Jie Ren，Qian-Qian Zhang，Yang-Yang Kong，Hai-Yan Zhang，Xiao-Hong Guo，Hui-Qin Fan，Li-Xin Liu 期刊:Biomedicine & Pharmacotherapy 影响因子:3.743 PMID:31152924

《Activation of the p38/MAPK pathway regulates autophagy in response to the CYPOR-dependent oxidative stress induced by zearalenone in porcine intestinal epithelial cells》 作者:Tongtong Shen,Yufan Miao,Chenchen Ding,Wentao Fan,Shuhui Liu,Yanan Lv,Xiaona Gao,MartheDe Boevre,Liping Yan,Sheila Okoth,Sarah De Saeger,Suquan Song 期刊:Food and Chemical Toxicology 影响因子:3.775 PMID:31173817