FITC标记的血红素氧合酶2抗体
产品名称： FITC标记的血红素氧合酶2抗体
英文名称： Anti-HO-2/FITC
产品编号： HZ-1238R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
- 联系人 : 鲍丽雯
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Rabbit Anti-HO-2/FITC Conjugated antibody
FITC标记的血红素氧合酶2抗体
| 英文名称 | Anti-HO-2/FITC |
| 中文名称 | FITC标记的血红素氧合酶2抗体 |
| 别 名 | Heme oxygenase (decycling) 2; Heme oxygenase (decyclizing) 2; HMOX 2; HMOX2; HMOX2 protein; HO 2; HO2; HMOX2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 合成与降解 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HO-2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Summary: catalyzes the conversion of heme to biliverdin; involved in cellular response to oxidative stress [SUBCELLULAR LOCATION] Microsome. Endoplasmic reticulum. [INDUCTION] Heme oxygenase 2 activity is non-inducible. [SIMILARITY] Belongs to the heme oxygenase family. Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Subcellular Location: Microsome. Endoplasmic reticulum. Similarity: Belongs to the heme oxygenase family. Contains 2 HRM (heme regulatory motif) repeats. Database links: Entrez Gene: 510243 Cow Entrez Gene: 479864 Dog Entrez Gene: 3163 Human Entrez Gene: 15369 Mouse Entrez Gene: 100009523 Rabbit Entrez Gene: 79239 Rat Omim: 141251 Human SwissProt: P30519 Human SwissProt: O70252 Mouse SwissProt: P43242 Rabbit SwissProt: P23711 Rat Unigene: 284279 Human Unigene: 272866 Mouse Unigene: 10241 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成与降解（Synthesis and Degradation） 血红素氧合酶是目前发现生物体内最易被诱导产生的抗氧化酶类，其抗氧化作用与它的催化分解产物即胆绿素、胆红素、NO、铁离子和铁蛋白有关。 血红素氧合酶-2基因缺失对血红素诱导的氧化应激性导致的组织损伤具有保护作用;选择性抑制神经元血红素氧合酶-2基因的表达可减轻氧化应激性组织细胞损伤. |
Heme oxygenase cleaves在α-甲基桥上的血红素环形成胆绿素。Biliverdin随后由biliverdin reductase转化为胆红素。在生理条件下，血红素加氧酶的活性在脾脏最高，脾脏中衰老的红细胞被隔离和破坏。血红素氧合酶2可能参与了大脑中一氧化碳的生成，它可以作为神经递质。概述：催化血红素转化为胆绿素；参与细胞对氧化应激的反应[亚细胞定位]微粒体。Endoplasmic reticulum。[诱导]血红素加氧酶2活性是不诱导的。[相似性]属于血红素加氧酶家族。