Necdin,生长抑制蛋白NDN抗体

产品编号HZ-6390R
英文名称Necdin
中文名称生长抑制蛋白NDN抗体
别 名HsT16328; NDN; NECD_HUMAN; Necdin; Necdin homolog.
规格价格0.1ml/980元 购买 0.2ml/1580元 购买
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 细胞周期蛋白 细胞类型标志物 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
Necdin,生长抑制蛋白NDN抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量36kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Necdin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Necdin,生长抑制蛋白NDN抗体PubMedPubMed
产品介绍background:
This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.

Function:
Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences.

Subunit:
Binds to the transactivation domains of E2F1 and p53. Binds also SV40 large T antigen and adenovirus E1A. Interacts with nucleobindin 1 and 2

Subcellular Location:
Perikaryon. Nucleus. Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.

Necdin,生长抑制蛋白NDN抗体Tissue Specificity:
Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post-mitotic neurons.

Similarity:
Contains 1 MAGE domain.

Gene ID:
4692

Database links:
Entrez Gene: 4692 Human
Entrez Gene: 17984 Mouse
Entrez Gene: 308690 Rat
Omim: 602117 Human
SwissProt: Q99608 Human
SwissProt: P25233 Mouse
Unigene: 50130 Human
Unigene: 400253 Mouse
Unigene: 3096 Rat

Necdin,生长抑制蛋白NDN抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.