NFKB2,p100-specific 抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
NFKB2,p100-specific 抗体

NFKB2,p100-specific 抗体

商家询价

产品名称： NFKB2,p100-specific 抗体

英文名称： NFKB2,p100-specific Antibody

产品编号： XY15504-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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 NFKB2,P100-SPECIFIC 抗体Applications

Tested Applications: ELISA
Specificity Reaction: Human,Mouse,Rat; Other species are not tested.Please decide the specificity by homology
Recommended dilution  
 NFKB2,P100-SPECIFIC 抗体Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Product Information
Source: Rabbit Purify: Antigen affinity purification
IsoType: IgG Storage: PBS with 0.1% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles.
Immunogen Information NFKB2,P100-SPECIFIC 抗体
Immunogen: Peptide Full Name: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Caculated Molecular
Weight:		 97 kDa Observed Molecular 
Weight:		  
GenbankNo BC002844 GeneID: 4791
Symbol NFKB2 Synonyms DNA binding factor KBF2, H2TF1, LYT 10, LYT10, NFKB2,p100, NFKB2,p52,p100, Oncogene Lyt 10, p100, p52
Background

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. P52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. P52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. This antibody can bind p100 isoform of NFKB2 spefically, but not p52 isoform. NFKB2,P100-SPECIFIC 抗体

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