FITC标记的E3泛素蛋白连接酶亚基KPC2抗体
产品名称： FITC标记的E3泛素蛋白连接酶亚基KPC2抗体
英文名称： Anti-KPC2/FITC
产品编号： HZ-16801R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-KPC2/FITC Conjugated antibody
FITC标记的E3泛素蛋白连接酶亚基KPC2抗体
| 英文名称 | Anti-KPC2/FITC |
| 中文名称 | FITC标记的E3泛素蛋白连接酶亚基KPC2抗体 |
| 别 名 | UBAC1_HUMAN; Ubiquitin-associated domain-containing protein 1; UBA domain-containing protein 1; E3 ubiquitin-protein ligase subunit KPC2; Glialblastoma cell differentiation-related protein 1; Kip1 ubiquitination-promoting complex protein 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 泛素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KPC2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: KPC2 (Kip1 ubiquitylation-promoting complex 2) together with KPC1 forms the ubiquitin ligase KPC, which regulates degradation of the cyclin-dependent kinase inhibitor p27 at the G1 phase of the cell cycle. KPC2 contains a ubiquitin-like (UBL) domain, two ubiquitin-associated (UBA) domains, and a heat shock chaperonin-binding (STI1) domain. Function: Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. Subunit: Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with RNF123 via its N-terminal domain. Interacts with the proteasome via its N-terminal domain. Subcellular Location: Cytoplasmic Similarity: Ubiquitous. Contains 1 STI1 domain. Contains 2 UBA domains. Contains 1 ubiquitin-like domain. Database links: Entrez Gene: 10422 Human Entrez Gene: 98766 Mouse Entrez Gene: 362087 Rat Omim: 608129 Human SwissProt: Q9BSL1 Human SwissProt: Q8VDI7 Mouse SwissProt: Q5XIR9 Rat Unigene: 9194 Human Unigene: 247824 Mouse Unigene: 6512 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
KPC2(Kip1泛素化促进复合物2)与KPC1一起形成泛素连接酶KPC，在细胞周期的G1期调节细胞周期素依赖性激酶抑制剂p27的降解。KPC2包含泛素样结构域（UBL）、两个泛素相关结构域（UBA）和热休克伴侣结合结构域（STI1）。