SDHC Pre-design Chimera RNAi
产品名称： SDHC Pre-design Chimera RNAi
英文名称： SDHC Pre-design Chimera RNAi
产品编号： H00006391-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 所在区域 : 台湾
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- Specification
- Product Description:
- Homo sapiens succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa (SDHC), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_001035511
- Target Region:
- 3' Untranslated Region (3'UTR)
- Note:
- Position of the Chimera RNAi.
The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence. -
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 6391
- Gene Name:
- SDHC
- Gene Alias:
- CYB560,CYBL,PGL3,QPS1,SDH3
- Gene Description:
- succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. Several related pseudogenes are located in different genomic regions. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq
- Other Designations:
- OTTHUMP00000032375,cytochrome B large subunit of complex II,integral membrane protein CII-3,integral membrane protein CII-3b,succinate dehydrogenase complex, subunit C,succinate dehydrogenase cytochrome b560 subunit,succinate-ubiquinone oxidoreducatase cy
- Gene Pathway
- Alzheimer's disease
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Citrate cycle (TCA cycle)
- Huntington's disease
- Metabolic pathways
- Oxidative phosphorylation
- Parkinson's disease
- Related Disease
- Adrenal Gland Neoplasms
- Atrophy
- Bone Neoplasms
- Carcinoma, Medullary
- Carcinoma, Renal Cell
- Carotid Body Tumor
- Genetic Predisposition to Disease
- Glomus Jugulare Tumor
- Head and Neck Neoplasms
- Helicobacter Infections
- Infertility, Male
- Kidney Neoplasms
- Lymphatic Metastasis
- Multiple endocrine neoplasia
- Multiple Endocrine Neoplasia Type 2a
- Neurofibromatosis
- Paraganglioma
- Pheochromocytoma
- Prostatic Neoplasms