RNASEL monoclonal antibody, clone 2E9
产品名称： RNASEL monoclonal antibody, clone 2E9
英文名称： RNASEL monoclonal antibody, clone 2E9
产品编号： MAB2378
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against full length recombinant RNASEL.
- Immunogen:
- Recombinant protein corresponding to full length human RNASEL.
- Host:
- Mouse
- Reactivity:
- Human, Primates
- Specificity:
- This antibody is specific to human RNaseL.
- Form:
- Liquid
- Isotype:
- IgG1, kappa
- Storage Buffer:
- In PBS (0.1% sodium azide)
- Storage Instruction:
- Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
- Recommend Usage:
- Western Blot (1:1000-1:4000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.
Han JQ, Townsend HL, Jha BK, Paranjape JM, Silverman RH, Barton DJ.J Virol. 2007 Jun;81(11):5561-72. Epub 2007 Mar 7.
- 2.
- Germline mutations in the ribonuclease L gene in families showing linkage with HPC1.
Carpten J, Nupponen N, Isaacs S, Sood R, Robbins C, Xu J, Faruque M, Moses T, Ewing C, Gillanders E, Hu P, Bujnovszky P, Makalowska I, Baffoe-Bonnie A, Faith D, Smith J, Stephan D, Wiley K, Brownstein M, Gildea D, Kelly B, Jenkins R, Hostetter G, Matikainen M, Schleutker J, Klinger K, Connors T, Xiang Y, Wang Z, De Marzo A, Papadopoulos N, Kallioniemi OP, Burk R, Meyers D, Gronberg H, Meltzer P, Silverman R, Bailey-Wilson J, Walsh P, Isaacs W, Trent J.Nat Genet. 2002 Feb;30(2):181-4. Epub 2002 Jan 22.
- 3.
- Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
Wang L, Zhou A, Vasavada S, Dong B, Nie H, Church JM, Williams BR, Banerjee S, Silverman RH.Clin Cancer Res. 1995 Nov;1(11):1421-8.
- 4.
- 2-5A-dependent RNase molecules dimerize during activation by 2-5A.
Dong B, Silverman RH.J Biol Chem. 1995 Feb 24;270(8):4133-7.
- Applications
- Western Blot (Transfected lysate)
- Western blot analysis of RNASEL in transfected cells (0.1 ug) and Hey1B (100 ug), using RNASEL monoclonal antibody, clone 2E9 (Cat # MAB2378).
- Entrez GeneID:
- 6041
- Gene Name:
- RNASEL
- Gene Alias:
- DKFZp781D08126,MGC104972,MGC133329,PRCA1,RNS4
- Gene Description:
- ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq
- Other Designations:
- 2',5'-oligoisoadenylate synthetase-dependent,OTTHUMP00000033148,interferon-induced 2-5A-dependent RNase,ribonuclease 4,ribonuclease L
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Biliary Tract Neoplasms
- Breast cancer
- Breast Neoplasms
- Cardiovascular Diseases
- Colorectal Neoplasms
- Diabetes Complications
- Disease Progression
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Hepatitis C
- Inflammation
- Lung Neoplasms
- Metabolic Syndrome X
- Neoplasms
- Obesity
- Obesity