FITC标记的毒蕈碱型乙酰胆碱受体抗体
产品名称： FITC标记的毒蕈碱型乙酰胆碱受体抗体
英文名称： Anti-ChRM2/FITC
产品编号： HZ-0236R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-ChRM2/FITC Conjugated antibody
FITC标记的毒蕈碱型乙酰胆碱受体抗体
| 英文名称 | Anti-ChRM2/FITC |
| 中文名称 | FITC标记的毒蕈碱型乙酰胆碱受体抗体 |
| 别 名 | 7TM receptor; Acetylcholine receptor, muscarinic, 2; Acm2; Cholinergic receptor muscarinic 2; Cholinergic receptor, muscarinic 2, cardiac; Cholinergic receptor, muscarinic 2, isoform a; Cholinergic receptor, muscarinic 2a; Cholinergic receptor, muscarinic 2, isoform a; CHRM 2; CHRM2; chrm2a; CM2; FLJ43243; HM 2; HM2; M2; M2 muscarinic receptor; MGC120006; MGC120007; ACM2_HUMAN; Muscarinic acetylcholine receptor M2; Muscarinic M2 receptor; Acetylcholine receptor(M2). |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 52kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ChRM2 C-terminus |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008] Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Subunit: Interacts with ARRB1 and ARRB2. Interacts with GNB2L1/RACK1; the interaction regulates CHRM2 internalization. Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. DISEASE: Genetic variations in CHRM2 can influence susceptibility to major depressive disorder (MDD) [MIM:608516]. MDD is one of the most common psychiatric disorders. MDD is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning. Similarity: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily. Database links: Entrez Gene: 1129 Human Entrez Gene: 243764 Mouse Entrez Gene: 397498 Pig Entrez Gene: 81645 Rat Omim: 118493 Human SwissProt: P08172 Human SwissProt: Q9ERZ4 Mouse SwissProt: P06199 Pig SwissProt: P10980 Rat Unigene: 535891 Human Unigene: 448632 Mouse Unigene: 10752 Rat Unigene: 200974 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
毒蕈碱胆碱能受体属于G蛋白偶联受体的较大家族。这些受体的功能多样性由乙酰胆碱与这些受体的结合所限定，并且包括细胞应答，例如腺苷酸环化酶抑制、磷酸肌醇变性和钾通道介导。毒蕈碱受体影响乙酰胆碱在中枢神经系统和外周神经系统中的许多作用。毒蕈碱胆碱能受体2参与了心动过缓的调解和心脏收缩力的降低。该基因已描述多个交替剪接转录变体。[ RefSeq，JUL 2008 ]