FITC标记的G蛋白结合蛋白RAB10抗体
产品名称： FITC标记的G蛋白结合蛋白RAB10抗体
英文名称： Anti-RAB10/FITC
产品编号： HZ-11257R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RAB10/FITC Conjugated antibody
FITC标记的G蛋白结合蛋白RAB10抗体
| 产品编号 | bs-11257R-FITC |
| 英文名称 | Anti-RAB10/FITC |
| 中文名称 | FITC标记的G蛋白结合蛋白RAB10抗体 |
| 别 名 | GTP binding protein RAB10; Rab 10; Rab-10; RAB10 member RAS oncogene family; RAB10_HUMAN; Ras related GTP binding protein; Ras related GTP binding protein RAB10; Ras-related protein Rab-10. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RAB10 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Ras-related superfamily of guanine nucleotide binding proteins, which includes the Ral/Rec, Rap, R-Ras, and Rho/Rab subfamilies, exhibit 30-60% homology with Ras p21 (1). Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport (1,2). The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function (1-6). The possibility that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles (9). Several members of the Rab subfamily have been identified, each of which is found at a particular stage of a membrane transport pathway (3-8). Function: The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation of transportvesicles to their fusion with membranes. Rabs cycle between aninactive GDP-bound form and an active GTP-bound form that is ableto recruit to membranes different set of downstream effectorsdirectly responsible for vesicle formation, movement, tethering andfusion (By similarity). That Rab is mainly involved in thebiosynthetic transport of proteins from the Golgi to the plasmamembrane. Regulates, for instance, SLC2A4/GLUT4 glucosetransporter-enriched vesicles delivery to the plasma membrane. Inparallel, it regulates the transport of TLR4, a toll-like receptorto the plasma membrane and therefore may be important for innateimmune response. Plays also a specific role in asymmetric proteintransport to the plasma membrane within the polarized neuron andepithelial cells. In neurons, it is involved in axonogenesisthrough regulation of vesicular membrane trafficking toward theaxonal plasma membrane while in epithelial cells, it regulatestransport from the Golgi to the basolateral membrane. Moreover, mayplay a role in the basolateral recycling pathway and in phagosomematuration. According to PubMed:23263280, may play a role inendoplasmic reticulum dynamics and morphology controllingtubulation along microtubules and tubules fusion. [ENZYME REGULATION] Rab activation is generally mediated by aguanine exchange factor (GEF), while inactivation throughhydrolysis of bound GTP is catalyzed by a GTPase activating protein(GAP) (By similarity). That Rab is activated by the DENND4C guanineexchange factor (GEF). Subunit: Interacts with MYO5A; mediates the transport to theplasma membrane of SLC2A4/GLUT4 storage vesicles. Interacts withGDI1 and maybe with GDI2; negatively regulates RAB10 associationwith membranes and activation. Interacts (GDP-bound form) withLLGL1; the interaction is direct and promotes RAB10 associationwith membranes and activation through competition with the Rabinhibitor GDI1 (By similarity). Interacts with EXOC4; probablyassociates with the exocyst (By similarity). Subcellular Location: Cytoplasmic vesicle membrane; Lipid-anchor(Probable); Cytoplasmic side (Probable). Golgi apparatus,trans-Golgi network membrane (By similarity). Endosome membrane.Recycling endosome membrane. Cytoplasmic vesicle, phagosomemembrane (By similarity). Cell projection, cilium. Endoplasmicreticulum membrane. Note=Associates with SLC2A4/GLUT4 storagevesicles. Localizes to the base of the cilium. Transientlyassociates with phagosomes (By similarity). According toPubMed:23263280 localizes to the endoplasmic reticulum at domainsof new tubule growth. DISEASE: Belongs to the small GTPase superfamily. Rab family. Similarity: Belongs to the small GTPase superfamily. Rab family. Database links: Entrez Gene: 421994 Chicken Entrez Gene: 403958 Dog Entrez Gene: 19325 Mouse Entrez Gene: 50993 Rat SwissProt: P24409 Dog SwissProt: P61027 Mouse SwissProt: P35281 Rat Unigene: 378993 Mouse Unigene: 486858 Mouse Unigene: 65864 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
鸟嘌呤核苷酸结合蛋白的RAS相关超家族，包括RAL/REC、RAP、R-ras和罗镇/RAB亚家族，与Ras p21（1）具有30%至60%的同源性。积累的数据表明，RAB蛋白的重要作用，无论是在胞吞作用或生物合成蛋白质转运（1,2）。将新合成的蛋白质从内质网运输到高尔基复合体的各种堆栈和分泌囊泡，在每个阶段涉及载体囊泡的运动，该过程似乎涉及RAB蛋白功能（1-6）。Rab-蛋白质也可能引导分泌囊泡向质膜的胞吐作用的可能性是通过观察到在酵母中，SEC4蛋白，其与RAB蛋白同源40%，与分泌囊泡（9）相关。已经鉴定出RAB亚家族的几个成员，每个成员都在膜转运途径的特定阶段（3-8）中发现。