MLH1 (Human) Recombinant Protein (Q01)
产品名称: MLH1 (Human) Recombinant Protein (Q01)
英文名称: MLH1 (Human) Recombinant Protein (Q01)
产品编号: H00004292-Q01
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human MLH1 partial ORF ( NP_000240, 647 a.a. - 756 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- VPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC
- Theoretical MW (kDa):
- 37.84
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
- Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 4292
- GeneBank Accession#:
- NM_000249
- Protein Accession#:
- NP_000240
- Gene Name:
- MLH1
- Gene Alias:
- COCA2,FCC2,HNPCC,HNPCC2,MGC5172,hMLH1
- Gene Description:
- mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. [provided by RefSeq
- Other Designations:
- DNA mismatch repair protein Mlh1,MutL protein homolog 1
- Related Disease
- Adenocarcinoma
- Adenocarcinoma, Papillary
- Adenoma
- Anticipation, Genetic
- Ataxia telangiectasia
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Hepatocellular
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Papillary
- Carcinoma, Renal Cell
- Carcinoma, Squamous Cell
- Chromosomal Instability
- Chromosome Deletion
- Chronic Disease
- Colitis, Ulcerative
- Colon cancer
- Colonic Neoplasms