FITC标记的多肽N-乙酰氨基半乳糖转移酶1抗体
产品名称: FITC标记的多肽N-乙酰氨基半乳糖转移酶1抗体
英文名称: Anti-GALNT1/FITC
产品编号: HZ-13273R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GALNT1/FITC Conjugated antibody
FITC标记的多肽N-乙酰氨基半乳糖转移酶1抗体
英文名称 | Anti-GALNT1/FITC |
中文名称 | FITC标记的多肽N-乙酰氨基半乳糖转移酶1抗体 |
别 名 | GALNAC T1; GalNAc transferase 1; GalNAc-T1; GALNT 1; GALNT1; GALT1_HUMAN; Polypeptide GalNAc transferase 1; Polypeptide N acetylgalactosaminyltransferase 1; Polypeptide N-acetylgalactosaminyltransferase 1 soluble form; pp GaNTase 1; pp-GaNTase 1; Protein UDP acetylgalactosaminyltransferase 1; Protein-UDP acetylgalactosaminyltransferase 1; UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 1; UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 1 (GalNAc T1); UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 1; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 信号转导 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 64kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human GALNT1/GalNAc-T1 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosamine) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-T1, also known as GALNT1 (Polypeptide N-acetylgalactosaminyltransferase 1), is a ubiquitously expressed 559 amino acid single-pass type II membrane protein that localizes to the Golgi apparatus and, like other GalNAc-Ts, contains a stem region and a C-terminal ricin/lectin-like domain. GalNAc-T1 catalyzes the first reaction in O-linked oligosaccharide biosynthesis, namely the transfer of an N-acetyl-D-galactosamine residue to a protein acceptor. GalNAc-T1 uses calcium and manganese as cofactors. Due to alternative splicing events, two GalNAc-T1 isoforms are expressed. Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. Subcellular Location: Secreted and Golgi apparatus > Golgi stack membrane. Tissue Specificity: Widely expressed. Expressed in all tissues tested. Similarity: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Contains 1 ricin B-type lectin domain. Database links: Entrez Gene: 2589 Human Entrez Gene: 14423 Mouse Entrez Gene: 79214 Rat Omim: 602273 Human SwissProt: Q10472 Human SwissProt: O08912 Mouse SwissProt: Q10473 Rat Unigene: 514806 Human Unigene: 30249 Mouse Unigene: 10266 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
UDP-N-乙酰-α-D-半乳糖胺:多肽N-乙酰半乳糖胺基转移酶(GalNAc-T)家族是底物特异性蛋白,催化GalNAc(N-乙酰半乳糖胺)向丝氨酸和苏氨酸残基转移至各种蛋白质上,从而引发粘蛋白型O链。高尔基体中的ED糖基化。GalNAc-T1,也称为GALNT1(多肽N-乙酰半乳糖胺基转移酶1),是一种广泛表达的559个氨基酸单程II型膜蛋白,定位于高尔基体,与其他GalNAc-Ts一样,含有茎区和C端蓖麻毒素/凝集素样结构域。GalNAc-T1催化O连接寡糖生物合成中的第一反应,即N-乙酰-D-半乳糖胺残基向蛋白质受体的转移。GalNC-T1使用钙和锰作为辅因子。由于选择性剪接事件,表达了两个GalNC-T1亚型。