1) Cat. No.: TRC-N388550; 2) Chemical Name: Necrostatin-1; 3) CAS No.: 4311-88-0; 4) Mol. Formula: C13H13N3OS; 5) Mol. Weight: 259.33; 6) Packing Size: 50mg / 500mg; 7) Appearence: ; 8) Application Notes: Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.; 9) Synonym: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; 
5-(Indol-3-ylmethyl)-3-methyl-2-thiohydantoin; Nec 1;; 10) Solubility: ; 11) Storage condition: ; 12) References: Foresti, R., et al: J. Biol. Chem., 272, 18411 (1997); Cardenas, A., et al.: J. Neurochem., 74, 2041 (2000); Degterev, et al.: Nat. Chem. Biol., 1, 112 (2005); Hitomi, J., et al.: Cell, 135, 1311 (2008);