FITC标记的干扰素诱导35蛋白抗体
产品名称： FITC标记的干扰素诱导35蛋白抗体
英文名称： Anti-IFI35/FITC
产品编号： HZ-9704R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-IFI35/FITC Conjugated antibody
FITC标记的干扰素诱导35蛋白抗体
| 产品编号 | bs-9704R-FITC |
| 英文名称 | Anti-IFI35/FITC |
| 中文名称 | FITC标记的干扰素诱导35蛋白抗体 |
| 别 名 | IFI 35; Ifi-35; IFI35; IFP 35; IFP35; IN35; IN35_HUMAN; Interferon induced 35 kDa protein; Interferon-induced 35 kDa protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞凋亡 细胞周期蛋白 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IFI35 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Interferon family of proteins are able to alter the expression of a variety of target genes, thereby controlling various events within the cell. IFI-35 (Interferon-induced 35 kDa protein), also known as IFP35, is a 286 amino acid interferon-induced protein. Localized to the nucleus and expressed in macrophages, fibroblasts and epithelial cells, IFI-35 is a leucine zipper protein that can form homodimers, but, unlike most leucine zipper proteins, cannot bind DNA. Upon induction by IFN-? IFI-35 associates with Nmi (N-Myc-interacting protein), resulting in the formation of a high molecular weight complex that is thought to play a role in IFN-?signaling and cellular responses. Once complexed with Nmi, IFI-35 is unable to be degraded by the proteasome, suggesting that IFI-35 is protected from degradation only when needed by IFN-? Two isoforms of IFI-35 exist due to alternative splicing events. Function: Not yet known. Subunit: Homodimer. Also interacts with B-ATF. Subcellular Location: Nucleus. Nuclear following IFN treatment. Tissue Specificity: In a wide range of cell types, including fibroblasts, macrophages, and epithelial cells. Similarity: Belongs to the NMI family. Database links: Entrez Gene: 3430 Human Omim: 600735 Human SwissProt: P80217 Human Unigene: 632258 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Interferon家族的蛋白质能够改变多种靶基因的表达，从而控制细胞内的各种事件。IFI35（干扰素诱导的35 kDa蛋白），也称为IFP35，是一种286氨基酸的干扰素诱导蛋白。定位于细胞核并在巨噬细胞、成纤维细胞和上皮细胞中表达，IFI35是亮氨酸拉链蛋白，可以形成同型二聚体，但不像大多数亮氨酸拉链蛋白，不能结合DNA。IFN诱导后？IFI35与NMI（N-Myc相互作用蛋白）缔合，导致形成高分子量复合物，被认为在IFN-γ中起作用。信号和细胞反应。一旦与NMI络合，IFI35不能被蛋白酶体降解，表明IFI35仅在IFN-需要时才被保护免于降解。IFI 35的两种异构体由于选择性剪接事件而存在。