FITC标记的冷诱导RNA结合蛋白抗体
产品名称： FITC标记的冷诱导RNA结合蛋白抗体
英文名称： Anti-CIRBP/FITC
产品编号： HZ-7790R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CIRBP/FITC Conjugated antibody
FITC标记的冷诱导RNA结合蛋白抗体
| 英文名称 | Anti-CIRBP/FITC |
| 中文名称 | FITC标记的冷诱导RNA结合蛋白抗体 |
| 别 名 | A18 hnRNP; A18HNRNP; cirbp; CIRBP_HUMAN; CIRP; Cold inducible RNA binding protein; Cold-inducible RNA-binding protein; Glycine rich RNA binding protein; Glycine-rich RNA-binding protein CIRP. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞周期蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 19kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CIRBP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. Function: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. Subunit: Interacts with EIF4G1. Associates with ribosomes. Subcellular Location: Nucleus, nucleoplasm. Cytoplasm. Tissue Specificity: Ubiquitous. Post-translational modifications: Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity). Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation. Similarity: Contains 1 RRM (RNA recognition motif) domain. Database links: UniProtKB/Swiss-Prot: Q14011.1 Entrez Gene: 1153 Human Entrez Gene: 425789 Chicken Entrez Gene: 507120 Cow Entrez Gene: 476755 Dog Entrez Gene: 12696 Mouse Entrez Gene: 81825 Rat Omim: 602649 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
冷诱导mRNA结合蛋白通过稳定涉及细胞存活的基因的转录物在遗传毒性应激反应中起保护作用。作为翻译激活剂。在冷诱导的细胞增殖抑制中起重要作用。特异性结合应激反应转录本RPA2和TXN的3’-非翻译区（3’- UTRs）。作为翻译阻遏物（通过相似性）。当过度表达时促进应激颗粒（SGS）的装配。