FITC标记的肥大细胞膜抑制性受体Allergin1抗体
产品名称： FITC标记的肥大细胞膜抑制性受体Allergin1抗体
英文名称： Anti-Allergin-1/FITC
产品编号： HZ-7348R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Allergin-1/FITC Conjugated antibody
FITC标记的肥大细胞膜抑制性受体Allergin1抗体
| 英文名称 | Anti-Allergin-1/FITC |
| 中文名称 | FITC标记的肥大细胞膜抑制性受体Allergin1抗体 |
| 别 名 | C17orf60; MILR1_HUMAN; Chromosome 17 open reading frame 60. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Allergin-1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: As a major event in type Ⅰ allergic reaction,degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors (FcεRIs) on mast cell membrane,and is followed by the release of a battery of inflammatory mediators,such as histamine,leukotrienes and arachidonic acid,and these inflammatory mediators in turn induce a series of allergic symptoms.Recently,Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast cells.The crosslinking of Allergin-1 to FcεRIs on mast cells may inhibit the signal transduction from FcεRIs to intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM),generate ITIM inhibitory signals,which then participate in the regulation of mast cell degranulation,and finally block the initiation of allergic inflammation. Function: Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction. Subcellular Location: Cell membrane. Tissue Specificity: Expressed in myeloid cells (dendritic cells, macrophages and neutrophils, weak expression on B-cells but not in T-cells or natural killer cells), peripheral blood basophils and mast cells (at protein level). Post-translational modifications: N-glycosylated. Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Database links: Entrez Gene: 284021 Human SwissProt: Q7Z6M3 Human Unigene: 631749 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
肥大细胞脱颗粒是Ⅰ型变态反应中的一个重要事件，它是由肥大细胞膜上的特异性IgE和高亲和力IgE受体(FcεRIs)相互作用所触发，随后释放一组炎性介质，如组胺、白三烯和α雷公藤酸和这些炎症介质又诱导一系列过敏症状。近来发现过敏原-1是肥大细胞优先表达的免疫球蛋白样受体。过敏原-1与肥大细胞FcεRIs的交联可能抑制肥大细胞信号转导。从FcεRIs到细胞内免疫受体酪氨酸基抑制基序(ITIM)，产生ITIM抑制信号，参与肥大细胞脱颗粒的调控，并最终达到抑制目的。