FITC标记的己糖激酶1抗体
产品名称： FITC标记的己糖激酶1抗体
英文名称： Anti-Hexokinase 1/FITC
产品编号： HZ-3992R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Hexokinase 1/FITC Conjugated antibody
FITC标记的己糖激酶1抗体
| 英文名称 | Anti-Hexokinase 1/FITC |
| 中文名称 | FITC标记的己糖激酶1抗体 |
| 别 名 | Brain form hexokinase; dea; Glycolytic enzyme; HEXOKIN; Hexokinase PI; Hexokinase type I; Hexokinase, tumor isozyme; Hexokinase-1; Hexokinase-A; HK I; HK1; HK1 tb; Hk1-s; HK1-ta; HK1-tc; HKI; HXK1; HXK1_HUMAN; mHk1-s; BB404130; EC 2.7.1.1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 信号转导 激酶和磷酸酶 糖蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 101kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Hexokinase 1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose-6-phosphate. Four hexokinase isoenzymes have been identified, including hexokinase I (HXK I), hexokinase II (HXK II), hexokinase III (HXK III) and hexokinase IV (HXK IV, also designated glucokinase or GCK). Hexokinases I-III each contain an N-terminal cluster of hydrophobic amino acids. Glucokinase lacks the N-terminal hydrophobic cluster. The hydrophobic cluster is thought to be necessary for membrane binding. This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other hexokinases. HXK I has been shown to be expressed in brain, kidney and heart tissues as well as in hepatoma cell lines. HXK II is involved in the uptake and utilization of glucose by adipose and skeletal tissues. Of the hexokinases, HXK III has the highest affinity for glucose. Glucokinase is expressed in pancreatic beta cells where it functions as a glucose sensor, determining the “set point” for insulin secretion. Subunit: Monomer. Subcellular Location: Mitochondrion outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding. Tissue Specificity: Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific. DISEASE: Defects in HK1 are the cause of hexokinase deficiency (HK deficiency) [MIM:235700]. HK deficiency is a rare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature. Similarity: Belongs to the hexokinase family. Database links: Entrez Gene: 3098 Human Entrez Gene: 15275 Mouse Entrez Gene: 25058 Rat Omim: 142600 Human SwissProt: P19367 Human SwissProt: P17710 Mouse SwissProt: P05708 Rat Unigene: 370365 Human Unigene: 196605 Mouse Unigene: 11017 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
己糖激酶利用Mg ATP作为磷供体，催化细胞内葡萄糖代谢的第一步，葡萄糖转化为葡萄糖-6-磷酸。已鉴定出四个己糖激酶同工酶，包括己糖激酶I（HXK I）、hexokinase II（HXK II）、hexokinase III（HXKⅢ）和己糖激酶IV（HXK IV，也被指定为葡萄糖激酶或GCK）。己糖激酶IⅢ每一个都含有疏水性氨基酸的N-末端簇。葡萄糖激酶缺乏N-末端疏水簇。疏水簇被认为是膜结合所必需的。这证明了葡萄糖激酶对葡萄糖的亲和力比其他己糖激酶低。HXKⅠ在脑、肾、心脏组织以及肝癌细胞系中均有表达。HXKⅡ参与了脂肪和骨骼组织对葡萄糖的吸收和利用。在己糖激酶中，HXKⅢ对葡萄糖具有最高的亲和力。葡萄糖激酶是在胰岛β细胞中表达的，它起着葡萄糖传感器的作用，决定了胰岛素分泌的“设定点”。