FITC标记的锚蛋白重复结构域蛋白26抗体
产品名称： FITC标记的锚蛋白重复结构域蛋白26抗体
英文名称： Anti-ANKRD26/FITC
产品编号： HZ-9755R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-ANKRD26/FITC Conjugated antibody
FITC标记的锚蛋白重复结构域蛋白26抗体
| 产品编号 | bs-9755R-FITC |
| 英文名称 | Anti-ANKRD26/FITC |
| 中文名称 | FITC标记的锚蛋白重复结构域蛋白26抗体 |
| 别 名 | Ankrd26; Ankyrin repeat domain 26; Ankyrin repeat domain-containing protein 26; Ankyrin repeat domaincontaining protein 26; ANR26_MOUSE. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 干细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 196kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse ANKRD26 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD26 (ankyrin repeat domain-containing protein 26) is a 1709 amino acid protein that contains five ANK repeats. Expressed at high level in many tissues, including brain, liver, kidney and heart, ANKRD26 may be phosphorylated upon DNA damage by Atm or ATR. ANKRD26 is also expressed in the arcuate and ventromedial nuclei within the hypothalamus and in the ependyma and the circumventricular organs that act as an interface between the peripheral circulation and the brain. It is suggested that alterations in the gene encoding ANKRD26 may lead to obesity. Three isoforms of ANKRD26 exists due to alternative splicing events. Similarity: Contains 5 ANK repeats. Database links: Entrez Gene: 232339 Mouse Entrez Gene: 312667 Rat SwissProt: Q811D2 Mouse Unigene: 276116 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
锚蛋白是膜结合分子，在整合膜蛋白与基于血影蛋白的细胞骨架网络中发挥重要作用。锚蛋白基因突变导致严重的遗传性疾病，如致命性心律失常和遗传性球形红细胞增多症。AKRD26（锚蛋白重复结构域包含蛋白26）是含有五个氨基酸重复序列的1709氨基酸蛋白质。在包括脑、肝、肾和心脏在内的许多组织中高水平表达，ANKRD26可在ATM或ATR DNA损伤时磷酸化。AKRD26也表达于下丘脑内的弓形和腹内侧核，在室管膜和脑室周围的器官中起作用，其作为外周循环和大脑之间的界面。提示ANKRD26基因的改变可能导致肥胖。由于选择性剪接事件，存在三种ANKRD26异构体。