NXF1抗体Applications
| In-house applications |
ELISA, WB, IF Application not tested? Please see our Guarantee. |
| Published applications |
CoIP, FC, IF, IP, WB |
Publications |
4 citations –view here |
| Species specificity |
Human,Mouse,Rat; other species not tested. |
| Published Species |
Human, monkey |
|
Images
Prev1Next
 HeLa cells were subjected to SDS PAGE followed by western blot with 10328-1-AP(NXF1 antibody) at dilution of 1:600 Immunofluorescent analysis of HepG2 cells using 10328-1-AP( NXF1 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
|
| Positive WB detected in |
HeLa cells, HEK-293 cells |
| Positive IF detected in |
HepG2 cells |
| Recommended dilution |
WB : 1:200-1:2000
IF : 1:20-1:200 |
NXF1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information NXF1抗体
| Immunogen |
NXF1 fusion protein ag0413 |
Full name |
Nuclear RNA export factor 1 |
Calculated molecular
weight |
70 kDa |
Observed molecular
weight |
66-70 kDa |
GenBank accession
number |
BC004904 |
Gene ID (NCBI) |
10482 |
| Gene symbol |
NXF1 |
Synonyms |
DKFZp667O0311, MEX67, mRNA export factor TAP, nuclear RNA export factor 1, NXF1, TAP, Tip associated protein, Tip associating protein |
Background
|
Nuclear RNA export factor 1 (NXF1, synonyms: TAP, MEX67) is one member of a family of nuclear RNA export factors. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1(NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. This protein shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. NXF1 overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. NXF1抗体
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