FITC标记的子宫珠蛋白抗体
产品名称： FITC标记的子宫珠蛋白抗体
英文名称： Anti-Uteroglobin/FITC
产品编号： HZ-1935R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Uteroglobin/FITC Conjugated antibody
FITC标记的子宫珠蛋白抗体
| 英文名称 | Anti-Uteroglobin/FITC |
| 中文名称 | FITC标记的子宫珠蛋白抗体 |
| 别 名 | blastokinin; CC10; CC16; CCPBP; CCSP; Clara cell phospholipid binding protein; Clara cell phospholipid-binding protein; clara cell secretory protein; Clara cell specific 10 kD protein; Clara Cells 10 kDa Secretory Protein; OTTHUMP00000236107; SCGB1A1; Secretoglobin family 1A member 1; Secretoglobin, family 1A, member 1 (uteroglobin); UG; UGB; UP-1; UP1; Urinary Protein 1; Urine Protein 1; UTER_HUMAN; Uteroglobin; Utg. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 8kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse Uteroglobin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Uteroglobin belongs to the family of secretoglobins and is a secreted protein product of nonciliated bronchiolar Clara cells. There is convincing data suggesting it has phospholipase A2 inhibitory activity, as well as, a number of other immunomodulatory features including inhibition of interferon gamma signalling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. Clara Cell Protein 16 concentrations have been determined in both serum and bronchoalveolar lavage fluid in numerous studies since 1994. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion. Function: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Subunit: Homodimer; antiparallel disulfide-linked. Subcellular Location: Secreted. Tissue Specificity: Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways). Similarity: Belongs to the secretoglobin family. Database links: Entrez Gene: 7356 Human Entrez Gene: 22287 Mouse Entrez Gene: 25575 Rat Omim: 192020 Human SwissProt: P11684 Human SwissProt: Q06318 Mouse SwissProt: P17559 Rat Unigene: 523732 Human Unigene: 2258 Mouse Unigene: 2206 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 子宫珠蛋白(uteroglobin)是一种类固醇诱导的类似细胞因子的多功能蛋白质，具有抗炎和免疫调节特性,它不仅在子宫内表达,而且可以在甲状腺,呼吸道,消化道，乳腺、胰腺、前列腺、脑垂体、睾丸等都有不同的表达 |
Uteroglobin属于分泌蛋白家族，是非纤毛细支气管克拉拉细胞分泌的蛋白产物。有令人信服的数据表明它具有磷脂酶A2抑制活性，以及许多其他免疫调节功能，包括抑制干扰素-γ信号转导和Th1与Th2淋巴细胞调节。它被认为是呼吸道上皮损伤和支气管功能障碍的潜在外周标记物。克拉拉细胞蛋白16浓度已在血清和支气管肺泡灌洗液中进行了大量的研究，自1994以来。在血清中，其增加与年龄、石棉、氯化氮和臭氧接触、结节病和高PEEP通气有关。在肺切除、矽肺暴露工人、吸烟者和哮*患者中，血清cc16水平降低。在各种机制（膈疝、糖尿病胎儿、Turner和唐氏综合征）引起的肺发育不全的胎儿羊水中也发现了C16的浓度降低。在胸膜腔积液中，cc16浓度与肺组织的扩散有关，如心肌胸膜充血中的高cc16水平。