FITC标记的锌指蛋白265抗体
产品名称： FITC标记的锌指蛋白265抗体
英文名称： Anti-ZRANB2/ZNF265/FITC
产品编号： HZ-16406R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ZRANB2/ZNF265/FITC Conjugated antibody
FITC标记的锌指蛋白265抗体
| 英文名称 | Anti-ZRANB2/ZNF265/FITC |
| 中文名称 | FITC标记的锌指蛋白265抗体 |
| 别 名 | ZRANB 2; DKFZp686J1831; DKFZp686N09117; FLJ41119; ZSC23_HUMAN OTTHUMP00000011240; OTTHUMP00000011241; Zinc finger protein 265; Zinc finger RAN binding domain containing 2; Zinc finger Ran binding domain containing protein 2; Zinc finger splicing; ZIS; ZIS1; ZIS2; ZNF265. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZRANB2/ZNF265 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1 or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family. Localized to the nucleus, ZNF265 functions as a splicing factor that is responsible for alternatively splicing Tra-2∫ (transformer-2 beta) transcripts and is thought to interfere with constitutive 5’-splice selection. ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity. Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR. Function: ZRANB2 is a splice factor required for alternative splicing of SFRS10/TRA2B transcripts. It may interfere with constitutive 5'-splice site selection. Subunit: Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1. Subcellular Location: Nuclear Post-translational modifications: Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the ZRANB2 family. Contains 2 RanBP2-type zinc fingers. Database links: Entrez Gene: 9406 Human Entrez Gene: 53861 Mouse Entrez Gene: 58821 Rat Omim: 604347 Human SwissProt: O95218 Human SwissProt: Q9R020 Mouse SwissProt: O35986 Rat Unigene: 194718 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
锌指蛋白含有DNA结合结构域，具有多种功能，其中大多数包含某种形式的转录激活或抑制。ZNF265(锌指蛋白265)，也称为ZRANB2(锌指Ran结合结构域含蛋白2)，ZIS，ZIS1或ZIS2，是属于ZRANB2家族的330个氨基酸蛋白。ZNF265定位于细胞核，起剪接因子的作用，它负责选择性剪接Tra-2(transformer-2beta)转录本，被认为干扰了组成性的5′剪接选择。ZNF265包含两个RANBP2型锌指，通过它传递其RNA结合活性。两个异构体，指定ZIS-1和ZIS-2，表达由于选择性剪接事件。DNA损伤时，ZIS-2可通过ATM或ATR磷酸化。