SRC polyclonal antibody
产品名称： SRC polyclonal antibody
英文名称： SRC polyclonal antibody
产品编号： PAB3435
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SRC.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human SRC.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- An increase in the expression and total activity of endogenous p60(c-Src) in several factor-independent mutants of a human GM-CSF-dependent leukemia cell line (TF-1).
Horn S, Meyer J, Stocking C, Ostertag W, Jucker M.Oncogene. 2003 Oct 16;22(46):7170-80.
- 2.
- Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma.
Hakam A, Fang Q, Karl R, Coppola D.Dig Dis Sci. 2003 Oct;48(10):1972-8.
- 3.
- v-SRC specifically regulates the nucleo-cytoplasmic delocalization of the major isoform of TEL (ETV6).
Lopez RG, Carron C, Ghysdael J.J Biol Chem. 2003 Oct 17;278(42):41316-25. Epub 2003 Jul 31.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of SRC polyclonal antibody (Cat # PAB3435) in mouse kidney tissue lysate. SRC (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with SRC polyclonal antibody (Cat # PAB3435) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 6714
- Protein Accession#:
- P12931
- Gene Name:
- SRC
- Gene Alias:
- ASV,SRC1,c-SRC,p60-Src
- Gene Description:
- v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
- Omim ID:
- 190090
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000174476,OTTHUMP00000174477,proto-oncogene tyrosine-protein kinase SRC,protooncogene SRC, Rous sarcoma,tyrosine kinase pp60c-src,tyrosine-protein kinase SRC-1
- Related Disease