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【4月文献战报】Bioss抗体新增高分文献精彩呈现

作者：北京博奥森生物技术有限公司 2023-06-21T09:37 (访问量:6891)

截止目前，引用Bioss产品发表的文献共24858篇，总影响因子116841.414分，发表在Nature, Science, Cell以及Immunity等顶级期刊的文献共58篇，合作单位覆盖了清华、北大、复旦、华盛顿大学、麻省理工学院、东京大学以及纽约大学等国际知名研究机构上百所。

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近期收录2023年4月引用Bioss产品发表的文献共288篇（图一，绿色柱），文章影响因子(IF) 总和高达2009.871，其中，10分以上文献47篇（图二）。

图一

图二

本文主要分享引用Bioss产品发表文章至Nature Nanotechnology, Immunity, Cancer Cell等期刊的5篇 IF＞15 的文献摘要，让我们一起欣赏吧。

Cell Discovery [IF=38.079]

文献引用抗体：bsm-41516M

Mouse Anti- SARS-CoV-2 (2019-nCoV) Spike RBD mAb | WB

作者单位：北京大学未来技术学院生物医学工程系

摘要：Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has elicited a worldwide pandemic since late 2019. There has been ~675 million confirmed coronavirus disease 2019 (COVID-19) cases, leading to more than 6.8 million deaths as of March 1, 2023. Five SARS-CoV-2 variants of concern (VOCs) were tracked as they emerged and were subsequently characterized. However, it is still difficult to predict the next dominant variant due to the rapid evolution of its spike (S) glycoprotein, which affects the binding activity between cellular receptor angiotensin-converting enzyme 2 (ACE2) and blocks the presenting epitope from humoral monoclonal antibody (mAb) recognition. Here, we established a robust mammalian cell-surface-display platform to study the interactions of S-ACE2 and S-mAb on a large scale. A lentivirus library of S variants was generated via in silico chip synthesis followed by site-directed saturation mutagenesis, after which the enriched candidates were acquired through single-cell fluorescence sorting and analyzed by third-generation DNA sequencing technologies. The mutational landscape provides a blueprint for understanding the key residues of the S protein binding affinity to ACE2 and mAb evasion. It was found that S205F, Y453F, Q493A, Q493M, Q498H, Q498Y, N501F, and N501T showed a 3–12-fold increase in infectivity, of which Y453F, Q493A, and Q498Y exhibited at least a 10-fold resistance to mAbs REGN10933, LY-CoV555, and REGN10987, respectively. These methods for mammalian cells may assist in the precise control of SARS-CoV-2 in the future.

JOURNAL OF HEPATOLOGY

[IF=30.083]

文献引用抗体：bs-1278R

Anti-8-OHdG (DNA/RNA Damage) pAb | IHC

作者单位：美国明尼苏达州罗切斯特市梅奥诊所生物化学和分子生物学部

摘要：Background & Aims

The prevalence of non-alcoholic steatohepatitis (NASH)-driven hepatocellular carcinoma (HCC) is rising rapidly, yet its underlying mechanisms remain unclear. Herein, we aim to determine the role of hypoxia-inducible lipid droplet associated protein (HILPDA)/hypoxia-inducible gene 2 (HIG2), a selective inhibitor of intracellular lipolysis, in NASH-driven HCC.

Methods

The clinical significance of HILPDA was assessed in human NASH-driven HCC specimens by immunohistochemistry and transcriptomics analyses. The oncogenic effect of HILPDA was assessed in human HCC cells and in 3D epithelial spheroids upon exposure to free fatty acids and either normoxia or hypoxia. Lipidomics profiling of wild-type and HILPDA knockout HCC cells was assessed via shotgun and targeted approaches. Wild-type (Hilpda^fl/fl) and hepatocyte-specific Hilpda knockout

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